Differentially evolutionary pathways and their interactions in genes expressed in brain of human and macaque
Wang, Ju et al. (2021), Differentially evolutionary pathways and their interactions in genes expressed in brain of human and macaque, Dryad, Dataset, https://doi.org/10.5061/dryad.bk3j9kd94
This is a supplemtary figure showing the distribution of variance component corresponding to dN/dS or pN/pS of real and simulated pathways. Variance component for pathways was computed in the following way, i.e., 30 pathways (~10% of the 313 pathways analyzed) were randomly selected from the pathway set and the variance component due to differences between pathways of dN/dS (or pN/pS) was computed. Then, genes in the selected pathways were reshuffled and variance component corresponding to the simulated pathway sets were calculated based on the permuted dN/dS (or pN/pS) ratios. The procedure was repeated 5,000 times to construct the distribution of variance component of pathway set and the null distribution. If the genes in the same pathway do not share the same evolutionary properties, the distribution of the variance component due to differences between pathways should be similar to the null distribution. In each panel, the variance component of null distribution and real pathways are shown in dark and gray, respectively.