The Cambrian (Miaolingian; Wuliuan) Spence Shale Lagerstätte of northern Utah and southern Idaho is one of the most diverse Burgess Shale-type deposits of Laurentia. It yields a diverse fauna consisting of abundant biomineralized and locally abundant soft-bodied fossils, along a range of environments from shallow water carbonates to deep shelf dark shales. Panarthropods are the dominant component throughout the deposit, both in time and space, but while the trilobites and agnostoids are abundant, most of the soft-bodied taxa are only known from very few specimens. Additionally, the knowledge of the soft-bodied panarthropods is currently largely limited to locations in the Wellsville Mountains of northeastern Utah. This contribution describes 21 new soft-bodied panarthropods from six locations, including the first occurrences of soft-bodied panarthropods in the High-Creek, Smithfield Creek, Spence Gulch, and Two-Mile Canyon localities. Additionally, we report the presence of bradoriids, Branchiocaris pretiosa, Perspicaris? dilatus, Naraoia? sp., Thelxiope cf. T. palaeothalassia, and Tuzoia guntheri for the first time from the Spence Shale Lagerstätte, the first occurrence reported outside of the Burgess Shale for Thelxiope cf. T. palaeothalassia and the first Wuliuan occurrence of Tuzoia guntheri. We also report on a new hurdiid carapace element and additional specimens of Buccaspinea cooperi?, Dioxycaris argenta, Hurdia sp., and Tuzoia retifera. This new material improves our understanding of the panarthropod fauna of the Spence Shale Lagerstätte and substantially increases our understanding of the distribution of the described taxa in time and space.