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Data from: Rapid molecular evolution across amniotes of the IIS/TOR network

Citation

McGaugh, Suzanne E. et al. (2016), Data from: Rapid molecular evolution across amniotes of the IIS/TOR network, Dryad, Dataset, https://doi.org/10.5061/dryad.vn872

Abstract

Comparative analyses of central molecular networks uncover variation that can be targeted by biomedical research to develop insights and interventions into disease. The insulin/insulin-like signaling and target of rapamycin (IIS/TOR) molecular network regulates metabolism, growth, and aging. With the development of new molecular resources for reptiles, we show that genes in IIS/TOR are rapidly evolving within amniotes (mammals and reptiles, including birds). Additionally, we find evidence of natural selection that diversified the hormone-receptor binding relationships that initiate IIS/TOR signaling. Our results uncover substantial variation in the IIS/TOR network within and among amniotes and provide a critical step to unlocking information on vertebrate patterns of genetic regulation of metabolism, modes of reproduction, and rates of aging.

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