Objectives: To measure the SARS-CoV-2 seroprevalence in the Carabayllo district of Lima, Peru at the end of the first wave of the pandemic.

Methods: This was a cross-sectional study of the district with random bi-stage cluster sampling. We collected socio-demographic and clinical data as well as serum samples for SARS-CoV2 antibody testing.

Results: Among 2,014 subjects sampled, 59.93% were men. SAR-CoV-2 seropositivity was 24.88% (501/2014), and after adjusting for the sampling design effects and test performance, the seroprevalence in November/December 2020 was 22.4% (95% CI 22.35 - 27.63). Seropositivity varied by age, with participants aged 30-59 years old having the highest prevalence. Seropositivity in symptomatic patients (32%) was 1.5 times more than in asymptomatic ones (23%), and work away of home, age >18, COVID-19 home contact, obesity were risk factors of SARS-CoV-2.

Conclusions: The low seroprevalence after the first wave of pandemic in this community indicates that a high proportion of people remained susceptible. Infection was important among people who never reported symptoms. People with obesity had a higher risk of having SARS-Cov-2 infection.

This was a cross-sectional study of the district with random bi-stage cluster sampling. We collected socio-demographic and clinical data as well as serum samples for SARS-CoV2 antibody testing.