This dataset represents the values of Landsat-based spectral vegetation indices estimated for 1138 wetland sites included in the National Wetland Condition Assessment (NWCA) by the U.S. Environmental Protection Agency, represented by circular buffers with 40-m radius as described in Taddeo et al., Ecological Applications, In Press. Each spectral index is summarized as a mean and standard deviation of its 2011 maximum values for the Landsat pixels falling within the site boundaries. The dataset contains two spreadsheets: the "Data" providing spectral index values for each NWCA site as estimated in this study, and the "Metadata" one which spells the index abbreviations and provides names and links to other variables used in the study which are publicly available via NWCA online database.