https://doi.org/10.5061/dryad.k98sf7mfq

Description of the data and file structure

After screening 73 patients, 9 with incomplete data were excluded and 64 patients with complete clinical data were enrolled. The average age of the participants was 47 ± 19 years, and 39 (60.94%) were male. All patients tested negative for blood HIV antibody tests, whereas 53 (82.81%) patients tested positive for T-SPOT.TB assay. Based on international standards, 45 patients were diagnosed with TBM, including 18 definite and 27 probable cases. The remaining 19 patients were not diagnosed with TBM, including 8 possible and 11 non-TBM cases.

Sheet 1

Shows the medical records of all the enrolled patients that we collected.

The specifics are:

• column A represents gender (male 1, female 0)
• column B represents neurological symptoms (presence of central nervous system symptoms 1, asymptomatic 0)
• column C represents the presence of impaired consciousness (presence of impaired consciousness 1, absence of impaired consciousness 0)
• column D represents the condition of generalized discomfort (presence of generalized tuberculosis symptoms is 1, absence of symptoms is 0)
• column E represents the result of TSPOT (positive is 1, negative is 0)
• column F represents the condition of somatoform disorders (presence of symptoms is 1, absence of symptoms is 0)
• column G represents the condition of cranial nerve disorders (presence of neurological impairment manifestations is 1, absence of neurological impairment manifestations is 0)
• column H represents the appearance of the cerebrospinal fluid (turbidity is 1, clarification is 0)
• column I represents the number of cells in the cerebrospinal fluid (each cell indicates a specific cell value, 10*6/L)
• column J represents the cerebrospinal fluid lymphocyte ratio (greater than 50% is 1, less than 50% is 0)
• column K represents the cerebrospinal fluid glucose content (specific value is recorded in each cell, mmol/L)
• column L represents the cerebrospinal fluid chloride content (specific value is recorded in each cell, mmol/L)
• column M represents the cerebrospinal fluid protein content (specific value is recorded in each cell, mg/L)
• column N represents the cerebrospinal fluid ADA content (specific value is recorded in each cell, U/L)
• column O represents the presence of hydrocephalus on cranial MRI (presence is 1, absence is 0)
• column P represents the presence of basilar membrane thickening on cranial MRI (presence is 1, absence is 0)
• column Q represents the presence of tuberculoma on cranial MRI (presence is 1, absence is 0)
• column R represents the presence of cerebral infarction on cranial MRI (presence is 1, absence is 0)
• column S represents whether the chest CT image is consistent with tuberculosis (presence is 1, absence is 0)
• column T represents whether the chest CT image is consistent with hematogenous disseminated tuberculosis (presence is 1, absence is 0)
• column U represents whether Mycobacterium tuberculosis was detected by sputum bacteriologic testing (1 for clear tuberculosis, 0 for no bacteriologic basis for tuberculosis)
• column V represents the results of cerebrospinal fluid mNGS testing (1 for Mycobacterium tuberculosis, 0 for other bacteria listed as specific bacterial species, and 0 for no pathogenic bacteria detected)
• column W represents the number of pathogenic bacterial sequences (with specific values listed in each cell)
• column X represents the results of the cerebrospinal fluid Xper test results (1 for positive, 0 for negative)
• column Y represents cerebrospinal AFB smear test results (1 for positive, 0 for negative)
• column Z represents cerebrospinal fluid Mycobacterium tuberculosis culture results (1 for positive, 0 for negative)
• column AA represents the final clinical diagnosis (each cell lists the name of the specific meningitis disease, with no CNS lesions indicated by null)
• column AB categorizes the diagnosis (1 Confirmed TBM, 2 Possible TBM, 3 Essentially impossible TBM, 4 Ruled out TBM)
• column AC stands for eventual tuberculous meningitis (1 for TBM, 0 for non-TBM).

Sheet 2

In Excel, we used the dataset from sheet 2 for our statistics.

The specifics are:

• column A represents sex, male recorded as 1
• column B represents TSPOT results, positive recorded as 1
• columns C and D represent nanopore test results, Mycobacterium tuberculosis detected recorded as 1
• column E represents the number of Mycobacterium tuberculosis sequences
• column F represents Xpert test results, positive recorded as 1
• column G represents AFB smear test results, positive recorded as 1
• column H represents MTB culture test results, positive recorded as 1
• column I represents the final clinical diagnostic results, the diagnosis of tuberculous meningitis was recorded as 1

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